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Pavan Muttil Laboratory

Principal Investigator: Pavan Muttil, PhD

Associate Professor: Pharmaceutical Sciences

Laboratory Photo

Muttil Lab Staff

Contact the Laboratory

Lab Physical Address

2705 Frontier Ave Suite 208

Lab Mailing Address

Pharmaceutical Sciences
MSC09 5360
1 University of New Mexico
Albuquerque, NM 87131-0001

Phone: (505) 925-4635
Fax: (505) 925-4549
E-mail: PMuttil@salud.unm.edu

Research Interests

Research in the Muttil Laboratory is focused on developing novel dry powders for inhaled, oral, and transdermal vaccines and drugs against various infectious diseases and cancers. These dry powders are prepared using spray drying technology and are ultimately evaluated in different animal models for their efficacy.

Recent Research

Current Projects and Publications

1) Mechanisms of BCG failure and Rescued Protection using Pulmonary Vaccination
Publications:
Price, D. N.; Kusewitt, D. F.; Lino, C. A.; McBride, A. A.; Muttil, P. (2016). Oral Tolerance to Environmental Mycobacteria Interferes with Intradermal, but Not Pulmonary, Immunization against Tuberculosis. PLoS Pathog, 12(5), e1005614.
Muttil, P.; Price, D. N.; McBride, A. A. (2013). Pulmonary immunization for TB with live cell-based vaccines: the importance of delivery route. Therapeutic Delivery, 2(12), 1519-1522.

2) Formulation and Characterization of Spray-dried Virus-Like Particles vaccine
Publications:
Saboo, S.; Tumban, E.; Peabody, J.; Wafula, D.; Peabody, D. S.; Chackerian, B.; Muttil, P. (2016). Optimized Formulation of a Thermostable Spray-Dried Virus-Like Particle Vaccine against Human Papillomavirus. Molecular pharmaceutics, 13(5), 1646-1655.
Tumban, E.; Muttil, P.; Escobar, C. A. A.; Peabody, J.; Wafula, D.; Peabody, D. S.; Chackerian, B. (2015). Preclinical refinements of a broadly protective VLP-based HPV vaccine targeting the minor capsid protein, L2. Vaccine, 33(29), 3346-3353.

3) Thermostable Formulation of Live Bacterial Vaccines
Publications:
Kunda, N. K.; Wafula, D.; Tram, M.; Wu, T. H.; Muttil, P. (2016). A Stable Live Bacterial Vaccine. European Journal of Pharmaceutics and Biopharmaceutics, 103, 109-117.
Johnson, P. E.; Muttil, P.; MacKenzie, D.; Carnes, E. C.; Pelowitz, J.; Mara, N. A.; ... Brinker, C. J. (2015). Spray-Dried Multiscale Nano-biocomposites Containing Living Cells. ACS nano, 9(7), 6961-6977.
Price, D. N.; Kunda, N. K.; Ellis, R.; Muttil, P. (2016). Design and optimization of a temperature-stable dry powder BCG vaccine (in preparation)

4) Orthotopic Lung Cancer Mouse Imaging Model Using SPECT/CT
Publications:
McBride, A. A.; Price, D. N.; Norenberg, J. P.; MacKenzie, D. A.; Thompson, T. A.; & Muttil, P. (2014). A longitudinal, orthotopic mouse imaging model using modified hNIS-A549 human lung adenocarcinoma cells and SPECT/CT imaging. Cancer Research, 74(19 Supplement), 102-102.
Price, D. N.; McBride, A. A.; Anton, M.; Kusewitt, D. F.; Norenberg, J. P.; MacKenzie, D. A.; Thompson, T. A.; Muttil, P. (2016). Longitudinal assessment of lung cancer progression in mice using the sodium iodide symporter reporter gene and SPECT/CT imaging (Under review)

5) Combination Chemo- and Immunotherapy against Latent Pulmonary Tuberculosis
Abstracts:
Muttil, P.; Price, D.N.; McBride, A.A.; Kunda, N.K. (2015) Combined Chemotherapy and Immunotherapy against Pulmonary Tuberculosis. 3rd International Tuberculosis meeting, University of Parma, Italy.
Kunda, N.K.; Price, D. N.; McBride, A.A.; Muttil, P. (2015). Chemotherapy and Immunotherapy Combination Treatment against Pulmonary Tuberculosis. American Association of Pharmaceutical Scientists Annual Meeting & Exposition, Orlando, Florida

6) Amorphous powder formulations for oral delivery of poorly soluble drugs

7) Vaccine delivery using microneedles

8) Drug delivery using Nano-in-Microparticle magnetic targeting to the lung
Abstracts:
McBride, A. A.; Price, D. N.; Lamoureux, L. R.; Elmaoued, A. A.; Vargas, J. M.; Adolphi, N. L.; Muttil, Pavan. (2013). Preparation and characterization of novel magnetic nano-in-microparticles for site-specific pulmonary drug delivery. Molecular Pharmaceutics, 10(10), 3574-3581.